Discovery of new genes involved in the parasitism of cells by the tubercle bacillus

A European-Asian collaboration of scientists have identified ten virulence genes of the tubercle bacillus. The inactivation of these genes lessens the pathogenic effects of the bacillus. This discovery, published in the journal PLoS Pathogens, will make it possible in particular to propose original therapeutic strategies and to test novel anti-tuberculosis vaccine candidates. In order to obtain these results in only two weeks, the researchers developed a new screening technique. This innovative, rapid and efficient method could be easily transposed to other intracellular pathogens.

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