RD114 envelope proteins provide an effective and versatile approach to pseudotype lentiviral vectors
Thursday, September 30, 2010 - 10:21
in Biology & Nature
Therapeutic lentiviral vectors are emerging as vital tools for molecular medicine as evidenced by the growing number of clinical trials using these vector systems. From a basic research standpoint, lentiviral vectors are very intriguing substrates. On the one hand, the HIV-1 genome offers expanded cloning capacity and the capability to transduce nondividing cells such as hematopoietic stem cells (HSCs) and neurons. However, concerns associated with the potential risk of generating replication competent lentiviral particles require the removal of significant portions of the HIV genome, most notably the envelope protein (env).