Analysis of sperm differentiation reveals new mode of proteasome regulation

(Medical Xpress) -- Early in development, cells undergo a controlled demolition that helps to shape their raw, pliable material into the specialized forms they must have to do their jobs as adults. The process by which this occurs is also crucial later in the cell’s life, to take out potentially dangerous trash that routinely accumulates as it ages. New work from Rockefeller University has now provided a detailed genetic and biochemical understanding of how one protein helps modulate this sculptor and janitor of the cell, known as the proteasome. The findings improve our knowledge of how cells specialize, and could also lead to new tools for fighting cancer and degenerative disorders.

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