Modified genetic alphabet: Chemical evolution generates bacterial strain with artificial nucleotide in its genome

Tuesday, July 19, 2011 - 08:30 in Biology & Nature

(PhysOrg.com) -- Evolution is based on heredity, changes to the genetic material (mutation), and the natural selection of those organisms that are best suited to the given environmental conditions. An international team led by Rupert Mutzel at the Freie Universität of Berlin has now successfully emulated one particular evolutionary process in the laboratory. As the researchers report in the journal Angewandte Chemie, they were able to generate a bacterial strain whose genetic material contains an artificial building block in place of a natural one. Their success results from a special automated cultivation technique.

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