Cell transformation a la carte
Monday, October 3, 2011 - 18:00
in Biology & Nature
Researchers from the Haematopoietic Differentiation and Stem Cell Biology group at the Centre for Genomic Regulation (CRG), have described one of the mechanisms by which a cell (from the skin, for example) can be converted into another which is completely different (e.g., a neuron or hepatic cell). They have discovered that the cell transcription factor C/EBPα is a determinant factor in cell transdifferentiation. This differentiation mechanism can be applied to any of the cells of an organism. The scope of the study, published in the Proceedings of the Natural Academy of Sciences (PNAS), could profoundly influence the development of cell therapies. In all tissues, stem cells specialise to produce very different cell types.