Helium raises resolution of whole cell imaging

The ability to obtain an accurate three-dimensional image of an intact cell is critical for unraveling the mysteries of cellular structure and function. However, for many years, tiny structures buried deep inside cells have been practically invisible to scientists due to a lack of microscopic techniques that achieve adequate resolution at the cell surface and through the entire depth of the cell. Now, a new study published by Cell Press in the October 4th issue of Biophysical Journal demonstrates that microscopy with helium ions may greatly enhance both surface and sub-cellular imaging.

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