Researchers use whole-genome sequencing to monitor evolution of drug resistance in bacteria
(PhysOrg.com) -- Two research groups working independently have come up with two different ways to use whole-genome sequencing to follow the path bacteria take in developing resistance to anti-bacterial drugs. Such research could prove useful in figuring out ways to stop the evolutionary process, thereby safeguarding current anti-bacterial agents for future patients. Both groups have published papers describing their work in Nature Genetics. The first group has found a way to actually monitor the evolution of the E. coli bacteria over several generations as it’s exposed to three types of anti-bacterial agents. The second group has figured out a way to follow mutations in bacteria that occur after anti-bacterial agents have been discontinued.