Positive feedback and tumorigenesis: A vicious circle that promotes cell proliferation

Cancer cells are essentially immortal. The acquisition of an unlimited capacity to divide – the process of immortalization - is a central event in the genesis of tumors. Normally, cells are subject to stringent mechanisms which control their proliferation. Together these ensure that pre-malignant cells are induced to enter a senescent, non-dividing state or to undergo apoptosis, i.e. commit suicide.

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