Tumors elude anti-cancer drugs through 'fork reversal' repair
Tuesday, August 6, 2013 - 08:31
in Health & Medicine
In research recently published in Nature Structural & Molecular Biology, Alessandro Vindigni, Ph.D., associate professor of biochemistry and molecular biology at Saint Louis University, discovered how cancer cells respond to the damage caused by an important class of anti-cancer drugs, topoisomerase I inhibitors. The discovery points to opportunities to improve chemotherapeutic regimens based on topoisomerase I inhibitor treatment and limit their toxic side effects.