From a drop of blood, a clone

Over the last few decades, scientists have drawn upon a powerful arsenal of biotechnology techniques to establish a wide variety of genetically engineered mouse strains. These animals represent invaluable resources for studying mammalian development and disease, but many of these mouse lines are infertile or challenging to breed by conventional means. Atsuo Ogura and colleagues at the RIKEN BioResource Center have now developed a simplified cloning strategy that should make it easier for scientists to protect their painstakingly developed mouse lines.

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