Solving a complex protein problem

Many proteins undergo processing within cellular compartments called the endoplasmic reticulum and the Golgi apparatus. Transit between these structures is facilitated by transport vesicles, which bubble out from the membranes of these compartments with the help of specialized coat proteins (Fig. 1). While most proteins, or 'cargo', marked for transport are gathered up by direct interaction with the coat proteins, some only interact with coat proteins through intermediary 'cargo receptor' complexes.

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