Brain-on-a-chip axonal strain injury model highlights mitochondrial membrane potential threshold

Researchers from the Biomedical Engineering Department of Rutgers, The State University of New Jersey recently demonstrated the use of their "Brain-on-a-Chip" microsystem to assess specific effects of traumatic axonal injury. While their model uses the three dimensional cell structure and networks found in intact animals, it is capable of visualizing individual axons and their responses to mechanical injury. This is done by utilizing organotypic slices taken from specific areas in the brain that are susceptible to injury during a traumatic brain injury event.

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