Images of a nearly invisible mouse

Researchers at the RIKEN Quantitative Biology Center in Japan, together with collaborators from the University of Tokyo, have developed a method that combines tissue decolorization and light-sheet fluorescent microscopy to take extremely detailed images of the interior of individual organs and even entire organisms. The work, published in Cell, opens new possibilities for understanding the way life works—the ultimate dream of systems biology—by allowing scientists to make tissues and whole organisms transparent and then image them at extremely precise, single-cell resolution.

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