Biochemists gain new insights into biogenesis of ribosomes
A type of scaffolding on which specialised workers ply their trade helps in the manufacturing process of the two subunits from which the ribosome – the protein factory of the cell – originates. Biochemists at Heidelberg University discovered it after succeeding in getting a peek into the ribosomal "birthing room". While studying baker's yeast as the model organism, the researchers, in collaboration with colleagues from Ludwig Maximilian University of Munich, discovered a shell that envelops the smaller of the two subunits during the ribosome's formation. The results of the research could contribute to a greater understanding of ribosomopathies – abnormalities caused by impaired ribosome biogenesis. Because several medications also act on the biogenesis of ribosomes, the investigators hope to apply their findings to cancer research. The results of the research were published in the journal Cell.