Simple synthesis of CF2H-containing organic molecules
Tuesday, August 30, 2016 - 06:11
in Physics & Chemistry
Organofluorine compounds are important in the fields of pharmaceuticals, agrochemicals and functional materials, because incorporation of fluorine atoms into organic molecules frequently influences their medicinal actions as well as chemical and physical properties. In particular, difluoromethyl group (CF2H) is an intriguing structural motif, especially in medicinal chemistry, because it may provide a lipophilic hydrogen donor and act as bioisostere of alcohols and thiols.