Scientists decipher the multi-domain, full-length structure of the human smoothened receptor
Thursday, May 18, 2017 - 05:31
in Physics & Chemistry
A team of scientists led by the iHuman Institute of ShanghaiTech University in collaboration with Fudan University has determined the high-resolution crystal structure of the multi-domain human smoothened receptor. The results illustrate the allosteric domain-domain interactions within the receptor, and their role in smoothened activation. These new findings are published on May 17th, 2017 in Nature Communications, titled "Crystal structure of a multi-domain human smoothened receptor in complex with a super stabilizing ligand," by Zhang X-J et al.