Largest study of CRISPR-Cas9 mutations creates prediction tool for gene editing

Tuesday, November 27, 2018 - 14:00 in Biology & Nature

The largest study of CRISPR action to date has developed a method to predict the exact mutations CRISPR-Cas9 gene editing can introduce to a cell. Researchers at the Wellcome Sanger Institute edited 40,000 different pieces of DNA and analysed a thousand million resulting DNA sequences to reveal the effects of the gene editing and develop a machine learning predictive tool of the outcomes. This will assist researchers who are using CRISPR-Cas9 to research disease mechanisms and drug targets.

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