Chemists propose new approach to the synthesis of ABCD ring system of alpkinidine
Monday, February 3, 2020 - 10:40
in Physics & Chemistry
RUDN University chemists, together with Indian colleagues from Goa University, have synthesized an analog of alkaloid of alpkinidine, a substance with a signified cytotoxic effect. Before the team's research, there was no convenient way to synthesize such heterocycles. The authors were able to obtain an analog of alpkinidine using the Negishi reaction as a key stage (a palladium-catalyzed combination of aryl halides with organozincs) followed by annelation (completion) of an additional cycle to the resulting heterocyclic framework. The method could potentially become the basis for a scheme of the synthesis of alpkinidine. The article is published in ChemistrySelect.