How the epigenetic landscape modulates pioneer transcription factor binding
Wednesday, May 24, 2023 - 11:42
in Psychology & Sociology
Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children's Research Hospital are exploring how a type of transcription factor called a pioneer transcription factor accesses DNA even when it is tightly wound. Their work revealed how the epigenetic landscape influences transcription factor binding.