Peripheral induction of Alzheimer's-like brain pathology in mice

Pathological protein deposits linked to Alzheimer's disease and cerebral amyloid angiopathy can be triggered not only by the administration of pathogenic misfolded protein fragments directly into the brain but also by peripheral administration outside the brain. This is shown in a new study done by researchers at the Hertie Institute of Clinical Brain Research (HIH, University Hospital Tuebingen, University of Tuebingen) and the German Centre for Neurodegenerative Diseases (DZNE), to be published in Science on October 21, 2010...

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