Making 'Good' Fat From Muscle And Vice Versa

Wednesday, August 20, 2008 - 17:21 in Biology & Nature

A surprise discovery -- that calorie-burning brown fat can be produced experimentally from muscle precursor cells in mice -- raises the prospect of new ways to fight obesity and overweight, report Dana-Farber scientists. They demonstrated that a previously known molecular switch, PRDM16, regulates the creation of brown fat from immature muscle cells. They also determined that the process is a two-way street: Knocking out PRDM16 in brown fat cells can convert them into muscle cells.

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