New Clue Emerges For Cellular Damage In Huntington's Disease

Huntington's disease is caused by a single mutated gene that creates proteins with abnormally long repeats of the amino acid glutamine. These proteins misfold and clump together, damaging and eventually killing neurons. Yet the steps that trigger cell death have not been clarified. This study reports one early trigger: The misfolded proteins interfere with the cell's ability to move proteins marked for degradation out of the endoplasmic reticulum (a cell compartment that folds and processes proteins).

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