Blocking Immune Inhibitor Improves Response To HIV-like Virus, Prolongs Survival In Monkeys

PD-1 is an immune system receptor that hampers the ability of anti-viral killer cells to fight against chronic viral infections, including HIV, HCV and TB. Using an antibody that blocks PD-1, researchers safely and significantly improved both killer T-cell and antibody immune responses against simian immunodeficiency virus in severely infected rhesus macaque monkeys, leading to prolonged survival. PD-1 blockade potentially could be effective in treating humans with HIV or other chronic infectious diseases.

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