Converting Adult Somatic Cells To Pluripotent Stem Cells Using A Single Virus

Scientists have found a more efficient way to create induced pluripotent stem cells using a single virus vector instead of multiple viruses in the reprogramming process. The ability to combine four vectors into single "stem cell cassette" containing all four genes using a combination of 2A peptides and IRES dramatically improves iPS cell production efficiency -- 10 times higher than previously reported studies.

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