High urea levels in chronic kidney failure might be toxic after all

It is thought that the elevated levels of urea (the byproduct of protein breakdown that is excreted in the urine) in patients with end-stage kidney failure are not particularly toxic. However, researchers have now generated evidence in mice that high levels of urea are indeed toxic. Blocking the effects of high levels of urea might therefore be of benefit to patients with end-stage kidney disease.

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