Fundamental discovery about how gene expression functions in bacteria

Researchers have discovered and characterized a general mechanism that controls transcription elongation in bacteria. The mechanism relies on physical cooperation between a moving ribosome and RNA polymerase (RNAP) that allows for a precise adjustment of the transcriptional yield in response to translational needs. The study could lead to the development of new ways to interfere with bacterial gene expression and serve as a new target for antimicrobial therapy.

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