Epigenetic gene silencing may hold key to fatal lung vascular disease

A rare but fatal disease of blood vessels in the lung may be caused in part by aberrant silencing of genes rather than genetic mutation. Pulmonary arterial hypertension has been linked to genetic causes in a small percentage of patients. But researchers have now found that a form of epigenetics -- the modification of gene expression -- causes the disease in an animal model and could contribute to the disease in humans.

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