Over-abundant protein prompts neurodegenerative cascade: Shuts down cell communications, helps cause dementia

In diverse neurodegenerative diseases ranging from Parkinson's to Alzheimer's, researchers have long noted accumulations of a little-understood neuronal protein called alpha-synuclein. Pathological and genetic evidence strongly suggested that excessive alpha-synuclein played a role in the evolution of these diseases, but it was unclear how too much alpha-synuclein culminated in synaptic damage and neurodegeneration.

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