Mammalian aging process linked to overactive cellular pathway

Researchers have linked hyperactivity in the mechanistic target of rapamycin complex 1 cellular pathway to reduced ketone production in the liver, which is a well-defined physiological trait of aging in mice. During sleep or other times of low carbohydrate intake, the liver converts fatty acids to ketones, which are vital sources of energy during fasting, especially for the heart and brain. As animals age, their ability to produce ketones in response to fasting declines.

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