New resource to unlock the role of microRNAs

The first mammalian microRNA knockout resource -- mirKO -- will soon be released. This research toolbox of mutant mouse ES cells, in which individual or clustered groups of microRNA genes have been deleted, will help researchers define the role of microRNAs in health and disease. Using these tools researchers can create cells or mice lacking specific microRNAs, study expression using fluorescent markers, or inactivate the gene in specific tissues or at specific times in development.

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