Tuberculosis bacterium's outer cell wall disarms the body's defense to remain infectious

The bacterium that causes tuberculosis has a unique molecule on its outer cell surface that blocks a key part of the body's defense. New research suggests this represents a novel mechanism in the microbe's evolving efforts to remain hidden from the human immune system. The TB bacterium has a molecule on its outer surface called lipomannan that can stop production of an important protein in the body's immune cells that helps contain TB infection and maintain it in a latent state.

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