It's about time: Disrupted internal clocks play role in disease

Researchers have a possible explanation why some alcoholics develop liver disease: Disrupted circadian rhythms can push those vulnerable over the edge to disease. Mice whose internal clocks were out of sync with the light-dark cycle and mice with circadian disruption from a faulty gene were fed diets without and with alcohol. The results showed circadian rhythm disruption and alcohol is a destructive double hit that can lead to alcoholic liver disease.

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