Gene family that suppresses prostate cancer discovered

Direct genetic evidence has been reported that a family of genes, called microRNA-34, are bona fide tumor suppressors. The researchers showed in mice how interplay between genes p53 and miR-34 jointly inhibits another cancer-causing gene called MET. In absence of p53 and miR-34, MET overexpresses a receptor protein and promotes unregulated cell growth and metastasis.

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