New details on microtubules and how the anti-cancer drug Taxol works

Images of microtubule assembly and disassembly have been produced by researchers at the unprecedented resolution of 5 angstroms, providing new insight into the success of the anti-cancer drug Taxol and pointing the way to possible improvements. "This is the first experimental demonstration of the link between nucleotide state and tubulin conformation within the microtubules and, by extension, the relationship between tubulin conformation and the transition from assembled to disassembled microtubule structure," says a biophysicist on the study.

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