The Princess and the Pea: Cells' ultra-sensitivity for strong molecular forces in adhesion processes

Knowing how cells exert force and sense mechanical feedback in their microenvironment is crucial to understanding how they activate a wide range of cellular functions, such as cell reproduction, differentiation and adhesion. Now a more fine-grained picture of adhesion mechanics is emerging, thanks to a new tool developed in recent years called a "tension gauge tether," which allows scientists to measure cell mechanics at the single-molecule level.

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