How an RNA gene silences a whole chromosome

Researchers have discovered how an abundant class of RNA genes, called lncRNAs can regulate key genes. By studying an important lncRNA, called Xist, the scientists identified how this RNA gathers a group of proteins and ultimately prevents women from having an extra functional X-chromosome -- a condition in female embryos that leads to death in early development. These findings mark the first time that researchers have uncovered the mechanism of action for lncRNA genes.

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