Disrupting mitochondrial function could improve treatment of fungal infections

By identifying new compounds that selectively block mitochondrial respiration in pathogenic fungi, scientists have identified a potential antifungal mechanism that could enable combination therapy with fluconazole, one of today's most commonly prescribed fungal infection treatments. Severe, invasive fungal infections have a mortality rate of 30-50 percent and cause an estimated 1.5 million deaths worldwide annually. Current antifungal therapies are hampered by the increasingly frequent emergence of drug resistance and negative interactions that often preclude combination use.

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