Novel nanoscale detection of real-time DNA amplification holds promise for diagnostics
Thursday, September 8, 2016 - 05:02
in Physics & Chemistry
A novel label-free method of measuring DNA amplification in real time has now been developed by researchers. The technique detects changes in the refractive index of a laser beam passing through a sample liquid within silica nanochannels. Its high sensitivity allows accurate quantification of a 1,000-fold range of DNA concentrations, from 1 fM to 1 pM. The system has the potential for use as an inexpensive miniaturized method of medical diagnostics.