Altered Cardiac Muscle Cells Controllable With Light

Scientists have altered cardiac muscle cells to make them controllable with light and showed an ability to cause conditions such as arrhythmia in genetically modified mice, which opens up new possibilities for researching the development and therefore treatment of arrhythmias. Tobias Brügmann and his colleagues from the University of Bonn’s Institute of Physiology I used a “channelrhodopsin” for their experiments - a type of light sensor. At the same time, it can act as an ion channel in the cell membrane because when stimulated with blue light, this channel opens, and positive ions flow into the cell. This causes a change in the cell membrane’s pressure, which stimulates cardiac muscle cells to contract. read more

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