Antibiotics 2020 - Turning Bacteria Against Themselves

Bacteria attack with toxins designed to hijack or kill host cells but they have ways of protecting themselves from their own toxins.   Researchers have described one of these protective mechanisms, potentially paving the way for new classes of antibiotics that cause the bacteria's toxins to turn on themselves. Scientists determined the structures of a toxin and its antitoxin in Streptococcus pyogenes, common bacteria that cause infections ranging from strep throat to life-threatening conditions like rheumatic fever. In Strep, the antitoxin is bound to the toxin in a way that keeps the toxin inactive. read more

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