ATM Gene Linked To Increased Pancreatic Cancer Risk

A study in Cancer Discovery says mutations in the ATM gene may increase the hereditary risk for pancreatic cancer.Pancreatic cancer is one of the most morbid cancers, with less than 5 percent of those diagnosed with the disease surviving to five years. Approximately 10 percent of patients come from families with multiple cases of pancreatic cancer.Using next-generation sequencing, including whole genome and whole exome analyses, they identified ATM gene mutations in two kindreds with familial pancreatic cancer. When those initial findings were examined in a large series for patients, ATM mutations were present in four of 166 subjects with pancreatic cancer but were absent in 190 spousal control subsets.  read more

Read the whole article on

More from