3 Billion-Year-Old Antibiotic-Resistant Proteins Resurrected
Wednesday, February 27, 2013 - 16:32
in Health & Medicine
Scientists say they have done laboratory resurrections of several 2 to 3 billion-year-old proteins, ancient ancestors of the enzymes that enable today's antibiotic-resistant bacteria to shrug off huge doses of penicillins, cephalosporins and other modern drugs. Antibiotic resistance existed long before Alexander Fleming discovered the first antibiotic in 1928. Genes that contain instructions for making the proteins responsible for antibiotic resistance have been found in 30,000-year-old permafrost sediment and other ancient sites. The new study research focused on beta-lactamases, enzymes responsible for resistance to the family of antibiotics that includes penicillin, which scientists believe originated billions of years ago. read more