Is Zinc The Missing Link For Osteoarthritis Therapies?
Thursday, February 13, 2014 - 15:10
in Biology & Nature
Osteoarthritis is a leading cause of disability, characterized by the destruction of cartilage tissue in joints, but there is a lack of effective therapies because the underlying molecular causes have been unclear. A study published by Cell Press February 13th in the journal Cell reveals that osteoarthritis-related tissue damage is caused by a molecular pathway that is involved in regulating and responding to zinc levels inside of cartilage cells. A protein called ZIP8 transports zinc inside these cells, setting off a cascade of molecular events that result in the destruction of cartilage tissue in mice. The findings could lead to a new generation of therapies for osteoarthritis. read more