Metabolism And Explaining Healthy Obesity

25 percent of people who look obese are metabolically healthy and don't have a high risk of developing type 2 diabetes, even though obesity is a major risk factor for diabetes. A study finds a possible explanation, revealing that high levels of a molecule called heme oxygenase-1 (HO-1) are linked to poor metabolic health and an increased risk of type 2 diabetes in obese humans. Moreover, HO-1 inhibition improves metabolic health in obese mice, suggesting that HO-1 blockers could represent a promising new strategy for the treatment of metabolic disease. read more

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