An effective target of biological therapy for hepatocellular carcinoma
Monday, June 15, 2009 - 16:21
in Biology & Nature
It has been shown that constitutively activated STAT3 is detected in many HCC cell lines and tissues. This suggests that STAT3 is a promising molecular target for HCC gene therapy. RNA interference (RNAi) is a post-transcriptional gene-silencing mechanism, in which the homologous RNA sequences could be introduced into cells that inhibit the expression of a particular gene through the introduction of short interfering RNAs(siRNA). There were a large number of confirmed reports that RNAi targeting oncogene could successfully inhibit the growth of tumour cells in vitro and in vivo. Hence, RNAi has been turned into a potent technology for tumour therapy. Yet, there are no reports about targeting STAT3 by RNAi in HCC...