Two Signals -- From Within And Out Of Cell -- Specify Motor Neuron Differentiation

Monday, June 15, 2009 - 11:21 in Biology & Nature

Two signals -- an external one from retinoic acid and an internal one from the transcription factor Neurogenin2 -- cooperate to activate chromatin (the basic material of chromosomes), and help determine that certain nerve progenitor cells become motor neurons, according to new research.

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