Structure of key molecule in immune system provides clues for designing drugs

A research team has deciphered a key step in an evolutionarily old branch of the immune response. This system, called complement, comprises a network of proteins that "complement" the work of antibodies in destroying foreign invaders. Complement proteins mark both bacterial and dying host cells for elimination by the body's cellular cleanup services and have been implicated in at least 30 diseases. The findings provide a molecular scaffold for designing novel drug therapeutics.

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