miR loss may power maligant transformation in chronic leukemia
Thursday, July 5, 2012 - 16:00
in Biology & Nature
This study shows that loss of a particular molecule in chronic lymphocytic leukemia (CLL) shuts down normal cell metabolism and turns up alternative mechanisms that enable cancer cells to produce the energy needed to proliferate and invade neighboring tissue. The study shows that the molecule, miR-125b, is often lost in CLL, and that the loss is associated with a characteristic of cancer cells called the Warburg effect.