Molecule discovered that protects brain from cannabis intoxication

Two INSERM research teams recently discovered that pregnenolone, a molecule produced by the brain, acts as a natural defense mechanism against the harmful effects of cannabis in animals. Pregnenolone prevents THC, the main active principle in cannabis, from fully activating its brain receptor, the CB1 receptor, that when overstimulated by THC causes the intoxicating effects of cannabis. By identifying this mechanism, the INSERM teams are already developing new approaches for the treatment of cannabis addiction.

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