New shock-and-kill approach could eradicate barrier to curing HIV

Despite tremendous progress in combatting HIV-1 infection with antiretroviral therapy, there is still no cure for the disease because these drugs do not kill a hidden reservoir of infected cells in the body. A new study reveals a multipronged strategy for eradicating this latent reservoir and preventing HIV-1 from rebounding after treatment is stopped in mice. The findings suggest that a 'shock-and-kill' approach, combined with virus-fighting antibodies, could represent a promising strategy for curing HIV-1.

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